0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Commentary |

Potential for Revealing Individual-Level Information in Genome-wide Association Studies

Thomas Lumley, PhD; Kenneth Rice, PhD
JAMA. 2010;303(7):659-660. doi:10.1001/jama.2010.120.
Text Size: A A A
Published online

Extract

Genome-wide association studies1 generate large volumes of results. While the strongest signals are the focus of most reports, full online publication of thousands or millions of association results has been encouraged.2 These aggregate results may be valuable for future scientific research,3 but analysts have recently shown47 that the aggregate results actually may reveal information about participants. Specifically, if study participants' genetic information is available, large-scale reporting of population-level variant-disease associations enables easy reconstruction of individuals' disease states.

Figures in this Article

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Place holder to copy figure label and caption
Figure. Predicted and Observed Measurements of Left Ventricular Mass
Graphic Jump Location

To construct the predictions based on a hypothetical cohort of 12 612 individuals, additive models were fitted for each of 35 000 variants. The product of each regression coefficient and number of copies of each variant gives subject × variant predictors. Averaging these for each subject gives an overall prediction score. Finally, predictions of left ventricular mass are constructed by scaling these prediction scores to match the 25% and 75% percentiles of the observed left ventricular mass measurements. Thirty-five thousand independent variants were used, each with minor allele frequency 20%. Greater accuracy could be obtained with more variants. In line with the findings of Visscher and Hill,7 these results are not sensitive to the assumed minor allele frequency. The dashed diagonal line indicates perfect prediction.

Tables

References

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Web of Science® Times Cited: 10

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
PubMed Articles
Jobs
brightcove.createExperiences();