Published Online: March 29, 2014. doi:10.1001/jama.2014.2632.
Study concept and design: Kavousi, Leening, Nanchen, Greenland, Ikram, Hofman, Franco.
Acquisition, analysis, or interpretation of data: Kavousi, Leening, Nanchen, Graham, Steyerberg, Ikram, Stricker, Hofman, Franco.
Drafting of the manuscript: Kavousi, Franco.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Kavousi, Leening, Steyerberg, Stricker.
Obtained funding: Ikram, Hofman.
Administrative, technical, or material support: Leening, Graham.
Study supervision: Nanchen, Ikram, Stricker, Hofman, Franco.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Kavousi reports research grants from AXA Research fund (outside the submitted work). Dr Greenland reports consultancy for University of Pennsylvania, Medical College of Wisconsin, the National Heart, Lung, and Blood Institute, Ohio State University, and Rush University. Dr Graham reports speaker fees from Pfizer and MSD. Dr Steyerberg reports royalties from Springer. Dr Franco reports grants from Nestle and Metagenics (outside the submitted work). No other disclosures were reported.
Funding/Support: The Rotterdam Study is funded by Erasmus MC and Erasmus University, Rotterdam, the Netherlands; the Netherlands Organisation for Scientific Research (NWO); the Netherlands Organisation for Health Research and Development (ZonMw); the Research Institute for Diseases in the Elderly (RIDE); the Ministry of Education, Culture and Science; the Ministry for Health, Welfare and Sports; the European Commission (DG XII); and the Municipality of Rotterdam. Dr Kavousi is supported by the AXA Research Fund. Drs Leening and Stricker are supported by a grant from the ZonMw (HTA grant 80.82500.98.10208). Dr Franco works in ErasmusAGE, a center for aging research across the life course funded by Nestle Nutrition (Nestec Ltd), Metagenics Inc, and AXA.
Role of the Sponsors: Erasmus MC and Erasmus University, NWO, ZonMw, RIDE, the Ministry of Education, Culture and Science, the Ministry for Health, Welfare and Sports, the European Commission, the Municipality of Rotterdam; Nestlé Nutrition (Nestec Ltd), Metagenics Inc, and AXA had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; or decision to submit the manuscript for publication.
Disclaimer: Dr Greenland, JAMA senior editor, was not involved in the evaluation of or decision to publish this article.
Additional Contributions: We gratefully acknowledge the dedication, commitment, and contribution of the inhabitants, general practitioners, and pharmacists of the Ommoord district to the Rotterdam Study.