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Comment & Response |

Hypothermia for Bacterial Meningitis

Marko Kutleša, MD, PhD1; Dragan Lepur, MD, PhD1; Bruno Baršić, MD, PhD1
[+] Author Affiliations
1Department of Intensive Care Medicine and Neuroinfectology, University Hospital for Infectious Diseases “Dr Fran Mihaljević,” Zagreb, Croatia
JAMA. 2014;311(13):1357-1358. doi:10.1001/jama.2014.1751.
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To the Editor In the randomized clinical trial by Dr Mourvillier and colleagues,1 the authors found that induced hypothermia in adults with severe community-acquired bacterial meningitis did not improve the outcome and may even be harmful. Furthermore, the authors stated that such results could have important implications for future trials on hypothermia in such patients.

The results of this trial are in contrast with experimental studies and recent observations in case series.2,3 Therefore, several important issues regarding the recruitment and methods of this trial should be discussed.


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April 2, 2014
Bruno Mourvillier, MD; Michel Wolff, MD
1Réanimation Médicale et Infectieuse, Groupe Hospitalier Bichat-Claude Bernard, Paris, France
JAMA. 2014;311(13):1358. doi:10.1001/jama.2014.1478.
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