Author Contributions: Dr Rosendaal had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Bare, Reitsma, Rosendaal.
Acquisition of data: Bezemer, Bare.
Analysis and interpretation of data: Bezemer, Bare, Arellano, Reitsma.
Drafting of the manuscript: Bezemer.
Critical revision of the manuscript for important intellectual content: Bezemer, Bare, Arellano, Reitsma, Rosendaal.
Statistical analysis: Bezemer, Bare, Arellano.
Obtained funding: Rosendaal.
Administrative, technical, or material support: Bare, Arellano, Rosendaal.
Study supervision: Bare, Reitsma, Rosendaal.
Financial Disclosures: None reported.
Funding/Support: The Leiden Thrombophilia Study was supported by grant 89.063 from the Netherlands Heart Foundation. The Multiple Environmental and Genetic Assessment of Risk Factors for Venous Thrombosis was supported by grant NHS 98.113 from the Netherlands Heart Foundation, grant RUL 99/1992 from the Dutch Cancer Foundation, and grant 912-03-0332003 from the Netherlands Organisation for Scientific Research. Celera reimbursed the Leiden University Medical Center for collecting, providing, and shipping the samples. Dr Bezemer received support for training in genetic epidemiology from the Leducq Foundation (Paris, France) for the development of Transatlantic Networks of Excellence in Cardiovascular Research (grant 04 CVD 02).
Role of the Sponsor: The funding organizations had no role in the design and conduct of the study; in the collection, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript.