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Dopamine Reward Pathway in Adult ADHD

Alan J. Zametkin, MD
JAMA. 2010;303(3):232-234. doi:10.1001/jama.2009.1998.
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To the Editor: Dr Volkow and colleagues1 studied the biological basis of attention-deficit/hyperactivity disorder (ADHD), using positron emission tomography (PET) to assess dopamine transporters and D2/D3 receptors. This was a study of adult ADHD, which can be overdiagnosed because of symptom overlap with mood and anxiety disorders, and I am concerned that the methods used in this study to evaluate the participants for true ADHD may have been inadequate.

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References

January 20, 2010
Samuele Cortese, MD, PhD; F. Xavier Castellanos, MD
JAMA. 2010;303(3):232-234. doi:10.1001/jama.2009.1999.
January 20, 2010
Nora D. Volkow, MD; James M. Swanson, PhD; Jeffrey H. Newcorn, MD
JAMA. 2010;303(3):232-234. doi:10.1001/jama.2009.2000.
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