In a 2005 JAMA article, Dorsey and colleagues Article reported that financial support of biomedical research doubled between 1994 and 2003. In this issue, they report results of an updated analysis of publicly available data on biomedical research funding by federal, state, and local governments; private not-for-profit entities; and industry sources. Among the authors' findings was that the rate of increase in research spending has slowed since 2005, with a compounded, inflation-adjusted annualized growth rate of 3.4% in 2003-2007 compared with 7.8% in 1994-2003. They also report that the inflation-adjusted absolute level of funding from the National Institutes of Health and the pharmaceutical, biotechnology, and medical device industries appears to have decreased by 2% in 2008. In an editorial, Boat Article discusses trends in biomedical research funding and implications of funding patterns and priorities for researchers, institutions, and the public.