The emergence of multidrug-resistant bacteria and the rapid global spread of carbapenem-resistant Enterobacteriaceae (CRE) have recently captured public attention, and some have asked whether the ongoing public health and scientific “war” against drug-resistant microbes, particularly bacteria, can ever be won. In fact, the challenge of antimicrobial resistance is an enduring threat that likely will never be eliminated. The threat is due, in part, to the inherent ability of microbes to replicate rapidly and mutate, offering them an evolutionary advantage in fending off hazards to their survival. Addressing the threat of antimicrobial resistance is a never-ending challenge.
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