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Letters |

Typhoid Fever in the United States and Antibiotic Choice—Reply

Michael F. Lynch, MD, MPH; Eric D. Mintz, MD, MPH
JAMA. 2010;303(1):34-35. doi:10.1001/jama.2009.1936.
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In Reply: Dr Basnyat's comments highlight many of the current challenges in antimicrobial therapy for patients with typhoid fever. Fluoroquinolones have been widely used; however, their effectiveness depends on the susceptibility of the patient's Salmonella ser Typhi isolate and the type of fluoroquinolone.1 Gatifloxacin, a higher-generation fluoroquinolone, may be an alternative to older fluoroquinolones for S Typhi strains with decreased ciprofloxacin susceptibility.


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January 6, 2010
Buddha Basnyat, MD, MSc, FRCP(E)
JAMA. 2010;303(1):34-35. doi:10.1001/jama.2009.1935.
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