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Health Agencies Update |

Exenatide and Kidney Function

Bridget M. Kuehn
JAMA. 2009;302(24):2644. doi:10.1001/jama.2009.1847.
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The US Food and Drug Administration (FDA) is warning physicians that it has received reports of acute renal failure or renal insufficiency in 78 individuals who were treated with exenatide for type 2 diabetes.

From April 2005 through October 2008, the agency received 62 reports of acute renal failure and 16 reports of renal insufficiency in individuals taking the drug. More than 6.6 million exenatide prescriptions were dispensed during that period. Affected patients ranged in age from 23 to 83 years; 74 (95%) had medical conditions or took medications that elevated their risk for altered kidney function. Four of the patients died, 18 required dialysis (including 6 with no prior history of altered kidney function), and 2 had kidney transplants.

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