Author Contributions: Dr Seshadri had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Beiser, Seshadri.
Acquisition of data: Beiser, Tan, Au, Harris, Roubenoff, DeCarli, Wolf, Seshadri.
Analysis and interpretation of data: Lieb, Beiser, Vasan, Tan, Roubenoff, Auerbach, DeCarli, Seshadri.
Drafting of the manuscript: Lieb, Roubenoff, Seshadri.
Critical revision of the manuscript for important intellectual content: Beiser, Vasan, Tan, Au, Harris, Roubenoff, Auerbach, DeCarli, Wolf, Seshadri.
Statistical analysis: Beiser.
Obtained funding: Harris, Roubenoff, DeCarli, Wolf, Seshadri.
Study supervision: Seshadri.
Financial Disclosures: None reported.
Funding/Support: This work was supported by contracts N01-HC-25195, N01HV28178, RO1 DK080739, and 2K24HL04334 (awarded to Dr Vasan) from the National Institutes of Health and the National Heart, Lung, and Blood Institute; grants R01 AG16495, AG08122, AG033193, and AG031287 from the National Institute on Aging; and grant R01 NS17950 from the National Institute of Neurological Disorders and Stroke.
Role of the Sponsors: The sponsors had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript.
Disclaimer: The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Neurological Disorders and Stroke, the National Heart, Lung, and Blood Institute, the National Institute on Aging, or the National Institutes of Health.