Study concept and design: Weusten, Bisschops, Schoon, Ragunath, Bergman.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Phoa, van Vilsteren, Tijssen, Bergman.
Critical revision of the manuscript for important intellectual content: Phoa, Weusten, Bisschops, Schoon, Ragunath, Fullarton, Di Pietro, Ravi, Visser, Offerhaus, Seldenrijk, Meijer, ten Kate, Tijssen, Bergman.
Statistical analysis: Phoa, van Vilsteren, Tijssen, Bergman.
Obtained funding: Bisschops, Bergman.
Administrative, technical, or material support: Phoa, van Vilsteren, Bisschops, Schoon, Ragunath, Fullarton, Ravi, Visser, Offerhaus, Seldenrijk, ten Kate, Bergman.
Study supervision: Phoa, van Vilsteren, Tijssen, Bergman.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Bisschops reports receiving grant funding from the Fund for Scientific Research Flanders (FWO) during the conduct of the study. Dr Schoon reports receiving grant funding from AstraZeneca and personal fees from BEST-academia. Dr Ravi reports receiving personal fees from BEST-academia. No other disclosures were reported.
SURF Study Group: Steering Committee: Jacques Bergman, MD, PhD (principal investigator) and Jan Tijssen, PhD. Writing committee: Nadine Phoa, MD, Jan Tijssen, PhD, and Jacques Bergman, MD, PhD. Data and safety monitoring board: Nicholas J. Shaheen, MD, MPH (chair, gastroenterologist), Michael Vieth, MD, PhD (pathologist), and Joel H. Rubenstein, MD, MSc (gastroenterologist). Study investigators: the Netherlands: Bas Weusten, MD (St Antonius Ziekenhuis, Nieuwegein); Erik Schoon, MD (Catharina Ziekenhuis, Eindhoven); Jacques Bergman, MD, PhD (Academisch Medisch Centrum Amsterdam). Belgium: Raf Bisschops, MD (Universitair Ziekenhuis Gasthuisberg, Leuven). United Kingdom: Krish Ragunath, MD (Queens Medical Center, Nottingham); Grant Fullarton, MD (Royal Infirmary, Glasgow); Massimiliano Di Pietro, MD, and Rebecca Fitzgerald, MD (Addenbrookes Hospital, Cambridge). Ireland: Narayanasamy Ravi, MD, and Dermot O’Toole, MD (St James’s Hospital, Dublin). Germany: Oliver Pech, MD (Horst-Schmidt-Kliniken, Wiesbaden). Study pathologists: the Netherlands: Mike Visser, MD, Johan Offerhaus, MD, Fiebo ten Kate, MD, and Sybren Meijer, MD (Academisch Medisch Centrum Amsterdam); Cees Seldenrijk, MD (St Antonius Ziekenhuis, Nieuwegein).
Funding/Support: This investigator-initiated trial was supported, in part, by Covidien GI Solutions (formerly BÂRRX Medical) and by the Maag Lever Darm Stichting grant WO 07-60 from the Dutch Digestive Diseases Foundation. Covidien GI Solutions provided ablation devices and access to a central electronic data management system.
Role of the Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. Approval of the manuscript and the decision to submit the manuscript for publication were made by the steering committee.
Additional Contributions: We thank research fellows Roos E. Pouw, MD, Lorenza Alvarez Herrero, MD, and Wouter L. Curvers, MD (Academic Medical Center Amsterdam), for their help in setting up this trial; research nurses Carine M. Sondermeijer, BSc, Wilda D. Rosmolen, MSc, Brenda Elzer, MSc, and Ineke Verhulst (Academic Medical Center Amsterdam), Kim van der Meulen, BN (St Antonius Hospital Nieuwegein), Mirjam van Loon, BN (Catharina Hospital Eindhoven), and Hilde Willekens, BN (University Hospital Leuven), for their professional research support; and Martin Houben, MD (Hagaziekenhuis, Den Haag), Ed Schenk, MD (Isala Klinieken, Zwolle), Arnoud van Oijen, MD (Medisch Centrum Alkmaar), Antonius H. J. Naber, MD, and Jan M. H. van den Brande, MD (Tergooiziekenhuizen, Hilversum), Jeroen J. Kolkman, MD (Medisch Spectrum Twente, Enschede), Lubbertus C. Baak, M (Onze Lieve Vrouwe Gasthuis, Amsterdam), Pieter Scholten, MD (St Lucas Andreas Ziekenhuis, Amsterdam), Clarisse Böhmer, MD (Spaarne Ziekenhuis, Hoofddorp), and Rosalie C. Mallant-Hent, MD (Flevoziekenhuis, Almere), for helping to make the SURF trial possible. We thank the Fund for Scientific Research of Flanders for supporting the SURF trial in Belgium by providing a research grant to Dr Bisschops. We thank all patients for participating in this trial. No one received compensation for their contribution. We also thank Oliver Pech, MD (Horst-Schmidt-Kliniken, Wiesbaden), for his contribution in setting up this trial in Germany. He was compensated by Covidien GI solutions for international review board approval.