Author Contributions: Drs Messiaen and Legius had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Messiaen, Brems, Zackai, Vijzelaar, Ayada, Yoshimura, Legius.
Acquisition of data: Messiaen, Yao, Brems, Callens, Spencer, Arn, Babovic-Vuksanovic, Bay, Bobele, Cohen, Escobar, Eunpu, Grebe, Greenstein, Hachen, Irons, Kronn, Lemire, Lim, McDonald, Narayanan, Pearn, Pedersen, Powell, Shapiro, Skidmore, Tegay, Thiese, Zackai, Taniguchi, Okamoto, Korf.
Analysis and interpretation of data: Messiaen, Yao, Brems, Callens, Sathienkjkanchai, Denayer, Babovic-Vuksanovic, Leppig, Narayanan, Zackai, Okamoto, Yoshimura, Parret, Korf, Legius.
Drafting of the manuscript: Messiaen, Yao, Brems, Callens, Denayer, Greenstein, Pearn, Shapiro, Tegay, Thiese, Ayada, Okamoto, Yoshimura, Parret, Legius.
Critical revision of the manuscript for important intellectual content: Messiaen, Brems, Sathienkjkanchai, Denayer, Spencer, Arn, Babovic-Vuksanovic, Bay, Bobele, Cohen, Escobar, Eunpu, Grebe, Hachen, Irons, Kronn, Lemire, Leppig, Lim, McDonald, Narayanan, Pedersen, Powell, Shapiro, Skidmore, Zackai, Vijzelaar, Taniguchi, Korf, Legius.
Statistical analysis: Taniguchi, Okamoto, Legius.
Obtained funding: Messiaen, Yoshimura, Legius.
Administrative, technical, or material support: Messiaen, Yao, Brems, Callens, Sathienkjkanchai, Spencer, Arn, Bay, Escobar, Grebe, Hachen, Irons, Kronn, Lemire, Pearn, Vijzelaar, Okamoto, Parret, Korf, Legius.
Study supervision: Messiaen, Yoshimura, Legius.
Financial Disclosures: Mr Vijzelaar is a scientist employed by MRC-Holland, provider of commercially available multiplex ligation–dependent probe amplification assays. No other disclosures were reported.
Funding/Support: This work was supported by National Institute of Child Health and Human Development UAB Intellectual and Developmental Disabilities Research Center grant P30-HD038985(to Drs Messiaen and Korf); the Institute for Promotion of Innovation Through Science and Technology, Flanders, Belgium (to Ms Brems); research grants from the Fonds voor Wetenschappelijk Onderzoek Vlaanderen (G.0096.02; to Dr Legius); the Interuniversity Attraction Poles, granted by the Federal Office for Scientific, Technical and Cultural Affairs of Belgium (2007-2011; P5/25; to Dr Legius); a Concerted Action Grant from Katholieke Universiteit Leuven; special Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan (to Dr Yoshimura); and the Program for Promotion of Fundamental Studies in Health Sciences of the National Institute of Biomedical Innovation in Japan (to Dr Yoshimura); and a Children's Tumor Foundation Young Investigator Award (to Dr Parret). The Wilderman family provided a donation (to Dr Messiaen) to help support NF1 research for children with café au lait spots only.
Role of the Sponsor: The sponsors of the study had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; or preparation, review, or approval of the manuscript.
Additional Contributions: We thank the patients and their families for their support. We also thank the Wilderman family for their donation.
This article was corrected online for error in data on 6/22/2010, prior to publication of the correction in print.