We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Letters |

Complications Associated With Use of Bone-Morphogenetic Proteins in Spinal Fusion Procedures

Tomislav Smoljanovic, MD, PhD; Franjo Siric, MD; Ivan Bojanic, MD, PhD
JAMA. 2009;302(19):2090-2091. doi:10.1001/jama.2009.1639.
Text Size: A A A
Published online


To the Editor: Dr Cahill and colleagues1 assessed the prevalence, complications, and hospital charges associated with use of bone-morphogenetic proteins (BMPs) in a retrospective study of patients undergoing spinal fusion procedures from 2002 to 2006. Citing a study by Tumialán et al,2 the authors stated that there is growing support for decreased complications with smaller doses of BMP. Although this may be true for early local complications that have been described following BMP use in cervical fusion (such as edema, respiratory distress, and hematoma), it seems unlikely for other complications of BMP use in spinal interbody fusions, such as transient bone resorption of vertebral bodies. Resorptions, which occurred within the first few weeks after spinal interbody fusion procedures assisted with BMP, have been clinically insignificant in some patients, but in others have resulted in serious complications (spacer subsidence, loss of correction, spacer dislodgement, and failure of spinal fusion).3


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview




November 18, 2009
Kevin S. Cahill, MD, PhD, MPH; Elizabeth B. Claus, MD, PhD
JAMA. 2009;302(19):2090-2091. doi:10.1001/jama.2009.1640.
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.