0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Letters |

Postherpetic Neuralgia in Herpes Zoster

Muke Zhou, MD; Dong Zhou, MD; Li He, MD
JAMA. 2009;302(17):1862-1863. doi:10.1001/jama.2009.1580.
Text Size: A A A
Published online

Extract

To the Editor: In his Clinical Crossroads article discussing herpes zoster, Dr Whitley1 stated that our Cochrane review2 reported no benefit of valacyclovir for prevention of postherpetic neuralgia (PHN) at 4 or 6 months after rash onset. However, this is not accurate; our review did not include any trials of valacyclovir.

In addition, Whitley stated that “[p]revention of PHN is a major concern because antiviral drugs alone do not reliably prevent this complication.” Although the results of randomized controlled trials and meta-analyses showing that antiviral drugs reduce the risk of developing PHN can be challenged, the overall findings support the use of antiviral therapy for herpes zoster to reduce the duration or incidence of prolonged pain.3 Cut points used to define PHN have ranged from 1 to 6 months after onset of zoster2,4; using a definition of PHN as pain present for more than 30 days after the onset of rash caused by herpes zoster, our review2 indicates that antiviral drugs significantly reduce the incidence of PHN. We also note that recent evidence-based recommendations for the management of patients with herpes zoster recommend using antiviral therapy to decrease the incidence of PHN.3

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

November 4, 2009
Richard J. Whitley, MD
JAMA. 2009;302(17):1862-1863. doi:10.1001/jama.2009.1581.
CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();