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Gene-Environment Interactions and Depression

Christian Schwahn, PhD; Hans Jörgen Grabe, MD
JAMA. 2009;302(17):1859-1862. doi:10.1001/jama.2009.1577.
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To the Editor: In their meta-analysis, Dr Risch and colleagues1 reported on gene-environment interactions in depressive disorders, focusing on the interaction between the serotonin transporter promoter polymorphism and life events. They stated that “the samples, study designs, measures, and analyses were highly divergent across studies, thereby limiting the comparability of the studies and their evidence regarding replication.” However, the authors did not address 2 other problems arising from the methodology of their meta-analysis.

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November 4, 2009
Karestan C. Koenen, PhD; Sandro Galea, MD, DrPH
JAMA. 2009;302(17):1859-1862. doi:10.1001/jama.2009.1575.
November 4, 2009
Francis E. Lotrich, MD, PhD; Eric Lenze, MD
JAMA. 2009;302(17):1859-1862. doi:10.1001/jama.2009.1576.
November 4, 2009
Nina Rieckmann, PhD; Michael A. Rapp, MD, PhD; Jacqueline Müller-Nordhorn, MD, DPH
JAMA. 2009;302(17):1859-1862. doi:10.1001/jama.2009.1578.
November 4, 2009
Kathleen Ries Merikangas, PhD; Thomas Lehner, PhD; Neil J. Risch, PhD
JAMA. 2009;302(17):1859-1862. doi:10.1001/jama.2009.1579.
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