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Letters |

Gene-Environment Interactions and Depression

Francis E. Lotrich, MD, PhD; Eric Lenze, MD
JAMA. 2009;302(17):1859-1862. doi:10.1001/jama.2009.1576.
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To the Editor: We have some concerns with the meta-analysis by Dr Risch and colleagues,1 which examined the role of 5-HTTLPR in moderating the relationship between stress and depression. We agree with the authors that blanket acceptance of a robust and universal interaction between 5-HTTLPR and stress is unwarranted, and it is premature to translate this into clinical and forensic settings. However, the authors concluded that the original finding was not confirmed, despite numerous independent positive reports in the literature. Other conclusions should be considered.

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November 4, 2009
Karestan C. Koenen, PhD; Sandro Galea, MD, DrPH
JAMA. 2009;302(17):1859-1862. doi:10.1001/jama.2009.1575.
November 4, 2009
Christian Schwahn, PhD; Hans Jörgen Grabe, MD
JAMA. 2009;302(17):1859-1862. doi:10.1001/jama.2009.1577.
November 4, 2009
Nina Rieckmann, PhD; Michael A. Rapp, MD, PhD; Jacqueline Müller-Nordhorn, MD, DPH
JAMA. 2009;302(17):1859-1862. doi:10.1001/jama.2009.1578.
November 4, 2009
Kathleen Ries Merikangas, PhD; Thomas Lehner, PhD; Neil J. Risch, PhD
JAMA. 2009;302(17):1859-1862. doi:10.1001/jama.2009.1579.
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