In 1941, the Commission on Influenza of the Armed Forces Epidemiological Board (AFEB) established a comprehensive national research plan to address the most important unanswered scientific questions about influenza.1 The commission prioritized assessment of vaccine and immune serum prophylaxis efficacy but also defined a much broader scope of collaborative work across the academic, public health, and military sectors. The plan included evaluation of isolation and quarantine practices, environmental controls, and the effectiveness of masks to control infection; field studies to define the clinical, microbiologic, pathologic, and epidemiologic correlates of infection and disease for specific virus subtypes; and evaluation of treatment regimens, including prophylaxis for bacterial superinfections.
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