Author Contributions: Dr Gruber had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Drs Kastrinos, Mukherjee, Gruber, and Syngal contributed equally to the manuscript.
Study concept and design: Kastrinos, Mukherjee, Stoffel, Gruber, Syngal.
Acquisition of data: Kastrinos, Mukherjee, Tayob, Sparr, Raymond, Bandipalliam, Stoffel, Gruber, Syngal.
Analysis and interpretation of data: Kastrinos, Mukherjee, Tayob, Wang, Stoffel, Gruber, Syngal.
Drafting of the manuscript: Kastrinos, Mukherjee, Tayob, Wang, Sparr, Raymond, Bandipalliam, Stoffel, Gruber, Syngal.
Critical revision of the manuscript for important intellectual content: Kastrinos, Mukherjee, Stoffel, Gruber, Syngal.
Statistical analysis: Kastrinos, Mukherjee, Tayob, Wang, Stoffel, Gruber, Syngal.
Obtained funding: Gruber, Syngal.
Administrative, technical, or material support: Kastrinos, Sparr, Raymond, Bandipalliam, Syngal.
Study supervision: Mukherjee, Gruber, Syngal.
Financial Disclosures: Dr Gruber reported serving as an external advisor to Myriad Genetics Laboratories Inc (2008). Dr Syngal reporting serving as an external advisor to Myriad Genetics Laboratories Inc (2007). All other authors reported no financial disclosures.
Funding/Support: This work was supported in part by the grants R01CA81488, K24CA113433, R01CA97075, and 5P30CA46592 from the National Cancer Institute, The Karp Family, H.H. & M. Metals Inc Fund, and the Leake Gift for Pancreatic Cancer Research.
Role of the Sponsors: The funding organizations of this study had no role in the design and conduct of the study; in the collection, management, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript.
Additional Contributions: We thank Antonis Antoniou, PhD (Cancer Research UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, United Kingdom), and Mark Jenkins, PhD (Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, Department of Pathology, University of Melbourne, Australia), for the technical advice in the implementation of modified segregation analysis. Drs Antoniou and Jenkins were not compensated for their contributions.