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Letters |

Tamsulosin and Ophthalmic Adverse Events After Cataract Surgery—Reply

Chaim Bell, MD, PhD; Andrea Gruneir, PhD; Paula Rochon, MD, MPH
JAMA. 2009;302(10):1054-1055. doi:10.1001/jama.2009.1287.
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In Reply: While we understand that there may be some ambiguity in the isolated sentence quoted by Dr Ponce-de-Leon, we do not believe that the context of the full abstract results section suggests a direct comparison between exposed and unexposed cohort members. The second sentence states, “Two hundred eighty-four patients (0.3%) had an adverse event,” noting the overall adverse event rate in the entire cohort of men undergoing cataract surgery. The sentence describing the 7.5% and 2.7% adverse event rates was intended to refer to the proportions in the 280 cases and 1102 randomly matched controls. Moreover, the findings were reinforced by the final sentence that noted an estimated number needed to harm of 255, a statistic that incorporates absolute risk.1

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September 9, 2009
Sergio Ponce-de-Leon, MD
JAMA. 2009;302(10):1054-1055. doi:10.1001/jama.2009.1285.
September 9, 2009
Bruce I. Gaynes, OD, PharmD
JAMA. 2009;302(10):1054-1055. doi:10.1001/jama.2009.1286.
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