Author Contributions: Dr de Almeida had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: de Almeida, Al Khabori, Guyatt, Witterick, Lin, Nedzelski, Chen.
Acquisition of data: de Almeida, Al Khabori.
Analysis and interpretation of data: de Almeida, Al Khabori, Guyatt, Witterick, Lin, Nedzelski, Chen.
Drafting of the manuscript: de Almeida, Guyatt, Chen.
Critical revision of the manuscript for important intellectual content: de Almeida, Al Khabori, Guyatt, Witterick, Lin, Nedzelski, Chen.
Statistical analysis: de Almeida, Al Khabori, Guyatt.
Administrative, technical, or material support: Guyatt, Witterick, Lin, Nedzelski, Chen.
Study supervision: Guyatt, Chen.
Financial Disclosures: Dr Witterick reported being a member of the advisory board for Schering Canada and Abbott Laboratories and a consultant for Alcon Canada. No other authors reported financial disclosures.
Funding/Support: Dr de Almeida is supported by an educational grant for graduate studies from the Albert and Temmy Latner Family Foundation in conjunction with Dr Jeremy Freeman and the Samuel Lunenfeld Research Institute at Mount Sinai Hospital, Toronto, Ontario, Canada.
Role of the Sponsor: None of the funding organizations or sponsors had any role in the design and conduct of the study; the collection, management, analysis, or interpretation of the data; or the preparation, review, or approval of the manuscript.
Additional Contributions: We thank Adalberto Loloya, MD, MSc candidate, McMaster University, Hamilton, Ontario, Canada, and Rahit Eskicioglu, PhD, Department of Computer Sciences, University of Manitoba, Winnepeg, Canada, for translations of articles. We also thank Sachin Sud, MD, Interdeparmental Division of Critical Care, University of Toronto, Toronto, Ontario, Canada, for verification of publication bias analyses. We also thank the following authors for clarifications regarding trial data: Kedar Adour, MD, Department of Head and Neck Surgery, Kaiser Permanente Medical Center, Oakland, California; Ricardo Bento, MD, Department of Otolaryngology, University of Sao Paolo School of Medicine, Sao Paolo, Brazil; Naohito Hato, MD, Department of Otolaryngology, Ehime University School of Medicine, Ehime, Japan; Kazuhiro Kawaguchi, MD, Department of Otolaryngology, Yamagata University School of Medicine, Yamagata, Japan; Gianni Lagalla, MD, Department of Neurosciences, University of Ancona, Torrette, Italy; Ajit Roy, MD, Department of Neurology, St John's Medical College, Bangalore, India; Frank Sullivan, PhD, and Fergus Daly, PhD, Scottish School of Primary Care, University of Dundee, Dundee, Scotland; and Maria Vazquez, MD, Faculty of Medicine, Universidad de la Republica, Montevideo, Uruguay. None of these individuals received compensation for their contributions.