Typhoid fever, also known as enteric fever, is a disease caused by a bacterium called Salmonella enterica serotype Typhi (Salmonella Typhi). Although it can be life-threatening, there is a less than 1% death rate among infected persons in the United States. Infected persons can develop sustained fever of up to 104F (40C), weakness, stomach pain, and headache. A rash (rose spots) may accompany the infection. According to the Centers for Disease Control and Prevention (CDC), there are about 300 cases of typhoid fever in the United States each year. The majority are in persons returning from international travels. There are about 20 million cases of typhoid fever causing 200 000 deaths worldwide yearly. The August 26, 2009, issue of JAMA includes an article about antibiotic resistance in typhoid fever.