Author Contributions: Drs Shuldiner and Gurbel had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Shuldiner, Post, Faraday, Herzog, Gurbel.
Acquisition of data: Shuldiner, Bliden, Gandhi, Horenstein, Damcott, Pakyz, Tantry, Herzog, Gurbel.
Analysis and interpretation of data: Shuldiner, O’Connell, Bliden, Ryan, Damcott, Tantry, Gibson, Pollin, Post, Parsa, Mitchell, Faraday, Herzog, Gurbel.
Drafting of the manuscript: Shuldiner, Bliden, Tantry, Herzog, Gurbel.
Critical revision of the manuscript for important intellectual content: Shuldiner, O’Connell, Gandhi, Ryan, Horenstein, Damcott, Pakyz, Tantry, Gibson, Pollin, Post, Parsa, Mitchell, Faraday, Herzog, Gurbel.
Statistical analysis: O’Connell, Bliden, Mitchell, Gurbel.
Obtained funding: Shuldiner, Gurbel.
Administrative, technical, or material support: Shuldiner, Bliden, Ryan, Damcott, Pakyz, Tantry, Gibson, Herzog, Gurbel.
Study supervision: Shuldiner, Bliden, Faraday, Gurbel.
Financial Disclosures: Dr Faraday reported that he is a coinventor of a patent application on novel antithrombotic agents and their methods of use. Dr Gurbel reported receiving grant support from Schering-Plough, AstraZeneca, Bayer Healthcare, Sanofi-Aventis, Portola Pharmaceuticals, Daiichi-Sankyo, and Lilly; and receiving honoraria/consulting income from Schering-Plough, AstraZeneca, Bayer Healthcare, Sanofi-Aventis, Portola Pharmaceuticals, Daiichi-Sankyo, Lilly, and Pozen. No other authors reported disclosures.
Funding/Support: This study was supported by National Institutes of Health grants NIH U01 GM074518 and U01 HL084756, the Clinical Nutrition Research Unit of Maryland (P30 DK072488), the University of Maryland General Clinical Research Center (M01 RR 16500), the Baltimore Veterans Administration Geriatric Research and Education Clinical Center, and Sinai Hospital of Baltimore.
Role of the Sponsors: The funding organizations had no role in the design and conduct of the study; the collection, analysis, and interpretation of the data; or the preparation, review, or approval of the manuscript.
Additional Contributions: We gratefully acknowledge our Amish liaisons and field workers and the extraordinary cooperation and support of the Amish community, without which these studies would not have been possible.