Author Contributions: Dr Féart had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Portet, Dartigues, Scarmeas, Barberger-Gateau.
Acquisition of data: Féart, Barberger-Gateau.
Analysis and interpretation of data: Féart, Samieri, Rondeau, Amieva, Scarmeas, Barberger-Gateau.
Drafting of the manuscript: Féart.
Critical revision of the manuscript for important intellectual content: Samieri, Rondeau, Amieva, Portet, Dartigues, Scarmeas, Barberger-Gateau.
Statistical analysis: Féart, Samieri, Rondeau, Scarmeas.
Obtained funding: Dartigues, Barberger-Gateau.
Administrative, technical, or material support: Portet.
Study supervision: Scarmeas, Barberger-Gateau.
Financial Disclosures: None reported.
Funding/Support: The Three-City (3C) Study is conducted under a partnership agreement between the Institut National de la Santé et de la Recherche Médicale (INSERM), the Institut de Santé Publique et Développement of the Victor Segalen Bordeaux 2 University, and Sanofi-Aventis. The Fondation pour la Recherche Médicale funded the preparation and initiation of the study. The 3C Study is also supported by the Caisse Nationale Maladie des Travailleurs Salariés, Direction Générale de la Santé, Mutuelle Générale de l’Education Nationale, Institut de la Longévité, Regional Governments of Aquitaine and Bourgogne, Fondation de France, and Ministry of Research–INSERM Programme “Cohortes et collections de données biologiques.” Financial support for the 3C-COGINUT project was provided by the French National Research Agency (ANR-06-PNRA-005). Dr Féart was funded by Association France Alzheimer; Dr Samieri was funded by Aquitaine Regional Government.
Role of the Sponsors: The study sponsors had no role in the design and conduct of the study; the collection, management, analysis, and interpretation of the data; or the preparation, review, or approval of the manuscript.
Additional Contributions: We thank Ray Cooke, PhD (L.A.C.E.S., Université Bordeaux 2, France) for his compensated assistance in revising the English.