Author Contributions: Dr Chan had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Chan, Fuchs.
Acquisition of data: Chan, Ogino, Fuchs.
Analysis and interpretation of data: Chan, Ogino, Fuchs.
Drafting of the manuscript: Chan, Fuchs.
Critical revision of the manuscript for important intellectual content: Chan, Ogino, Fuchs.
Statistical analysis: Chan.
Obtained funding: Chan, Fuchs.
Administrative, technical, or material support: Chan, Ogino, Fuchs.
Study supervision: Chan, Fuchs.
Financial Disclosures: None reported.
Funding/Support: This work was supported by grants CA87969, CA55075, CA118553, CA127003, and CA137178 from the National Cancer Institute (NCI), National Institutes of Health (NIH). Dr Chan is a recipient of the Damon Runyon Cancer Research Foundation Clinical Investigator Award and a career development award from the NCI (CA107412). Dr Ogino is a recipient of a career development award from the NCI (CA122826).
Role of the Sponsor: The NCI, the NIH, and the Damon Runyon Cancer Research Foundation had no role in the design and conduct of the study; collection, management, analysis, or interpretation of the data; or preparation, review, or approval of the manuscript.
Previous Presentations: An abstract of this data was presented on June 1, 2009, at the clinical plenary session of the American Gastroenterological Association/Digestive Disease Week, Chicago, Illinois.