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Letters | August 12, 2009

Autologous Nonmyeloablative Hematopoietic Stem Cell Transplantation in Newly Diagnosed Type 1 Diabetes Mellitus—Reply

Júlio C. Voltarelli, MD, PhD; Edson Z. Martinez, PhD; Richard K. Burt, MD

JAMA. 2009;302(6):624-625. doi:10.1001/jama.2009.1100.

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In Reply: In response to Dr Gitelman and colleagues, most of the 160 screened patients were not eligible for the study either because of disease diagnosed for more than 6 weeks, absence of positive results from an anti–glutamic acid decarboxylase test, presence of previous ketoacidosis, or absence of evaluation for ketoacidosis. Approximately 30% of the patients eligible for the study were not willing to accept the risks of the procedure.

We performed weekly monitoring for cytomegalovirus infection in all patients. None of them developed primary infection or reactivation of cytomegalovirus or Epstein-Barr virus. We support research efforts to expand on our work on immune intervention in type 1 diabetes mellitus, with a goal of obtaining the same or better results with less toxicity.

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Figure. Kaplan-Meier Curve for Insulin-Free Survival

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The analysis included 20 patients without previous ketoacidosis who did not receive corticosteroids pretransplant. Vertical ticks indicate censored patients; dashed lines, 95% confidence interval; HSCT, autologous hematopoietic stem cell transplantation.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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August 12, 2009

Autologous Nonmyeloablative Hematopoietic Stem Cell Transplantation in Newly Diagnosed Type 1 Diabetes Mellitus

Stephen E. Gitelman, MD; Michael J. Haller, MD; Desmond Schatz, MD

JAMA. 2009;302(6):624-625. doi:10.1001/jama.2009.1098.

August 12, 2009

Autologous Nonmyeloablative Hematopoietic Stem Cell Transplantation in Newly Diagnosed Type 1 Diabetes Mellitus

Pablo R. Olmos, MD; Gisella Borzone, MD, PhD

JAMA. 2009;302(6):624-625. doi:10.1001/jama.2009.1099.

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Voltarelli JC, Martinez EZ, Burt RK. Autologous Nonmyeloablative Hematopoietic Stem Cell Transplantation in Newly Diagnosed Type 1 Diabetes Mellitus—Reply. JAMA. 2009;302(6):624-625. doi:10.1001/jama.2009.1100.

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