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Letters |

Clinical Practice Guidelines and Scientific Evidence

John Concato, MD, MS, MPH; Ralph I. Horwitz, MD
JAMA. 2009;302(2):142-147. doi:10.1001/jama.2009.914.
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To the Editor: Without commenting on the review of clinical practice guidelines in cardiovascular disease by Dr Tricoci and colleagues,1 we take issue with the corresponding Editorial by Drs Shaneyfelt and Centor2 regarding such guidelines in general. The Editorial endorsed a major assumption—also promoted as a tenet of evidence-based medicine—that data based on the highest level of evidence provide an unequivocal path to improved patient care.

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July 8, 2009
Susan L. Norris, MD, MPH, MS
JAMA. 2009;302(2):142-147. doi:10.1001/jama.2009.908.
July 8, 2009
Finlay A. McAlister, MD, MSc
JAMA. 2009;302(2):142-147. doi:10.1001/jama.2009.909.
July 8, 2009
Francesco Enia, MD
JAMA. 2009;302(2):142-147. doi:10.1001/jama.2009.910.
July 8, 2009
Christian M. Pettker, MD; Edmund F. Funai, MD
JAMA. 2009;302(2):142-147. doi:10.1001/jama.2009.911.
July 8, 2009
Elliott M. Antman, MD; Raymond J. Gibbons, MD
JAMA. 2009;302(2):142-147. doi:10.1001/jama.2009.912.
July 8, 2009
Mark D. Huffman, MD, MPH; Robert O. Bonow, MD
JAMA. 2009;302(2):142-147. doi:10.1001/jama.2009.913.
July 8, 2009
Robert S. Bobrow, MD
JAMA. 2009;302(2):142-147. doi:10.1001/jama.2009.915.
July 8, 2009
Shyam S. Kothari, MD
JAMA. 2009;302(2):142-147. doi:10.1001/jama.2009.916.
July 8, 2009
Pierluigi Tricoci, MD, MHS, PhD; Robert M. Califf, MD; Sidney C. Smith, MD
JAMA. 2009;302(2):142-147. doi:10.1001/jama.2009.917-a.
July 8, 2009
Terrence M. Shaneyfelt, MD, MPH; Robert M. Centor, MD
JAMA. 2009;302(2):142-147. doi:10.1001/jama.2009.918.
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