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Commentary |

The Need for Improved Access to FDA Reviews

Alec B. O’Connor, MD, MPH
JAMA. 2009;302(2):191-193. doi:10.1001/jama.2009.973.
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The medical literature is expanding rapidly, with thousands of new studies published each year. Increasingly, clinicians and scientists rely on rigorous syntheses of the scientific literature, such as high-quality systematic reviews and meta-analyses, which the Oxford Centre for Evidence-Based Medicine considers the highest level of scientific evidence available.1 However, systematic reviews and meta-analyses are typically based on the published literature, which is known to be biased,24 creating an important question: can we trust the highest level of evidence available in MEDLINE?

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