The use of genomics to prevent and treat disease is considered an important cornerstone for the future of health care. While the potential of genomics must be acknowledged, use of currently available scientific data and technical advances to reduce the burden of sickle cell disease (SCD), one of the most common serious single-gene disorders, is past due. However, any discussion of SCD must consider the historical context of race, inequalities in care,1 and previous concerns about authoritarian eugenics.2 The goal of this Viewpoint is to call attention to the unfulfilled promise of genetic screening to prevent SCD and to recommend necessary steps to realize this promise.
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