Author Contributions: Dr Annane had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Annane, Bellissant, Keh, Kupfer.
Acquisition of data: Annane, Bollaert, Briegel, Confalonieri, De Gaudio, Keh, Kupfer, Oppert, Meduri.
Analysis and interpretation of data: Annane, Bellissant, Bollaert, Briegel, Confalonieri, De Gaudio,Keh, Kupfer.
Drafting of the manuscript: Annane, Bellissant.
Critical revision of the manuscript for important intellectual content: Annane, Bellissant, Bollaert, Briegel, Confalonieri, De Gaudio, Keh, Kupfer, Oppert, Meduri.
Statistical analysis: Annane, Bellissant, Kupfer.
Obtained funding: Annane, Kupfer.
Administrative, technical, or material support: Annane, Bollaert, Briegel, Keh, Kupfer, Oppert.
Study supervision: Annane, Bellissant, Briegel, Confalonieri.
Financial Disclosures: The following authors of this review have been involved in randomized controlled trials of low-dose hydrocortisone, which are included in this review: Dr Annane18,22; Dr Bellissant18; Dr Bollaert15,18; Dr Briegel16,22; Dr Confalonieri50; Dr De Gaudio53; Dr Keh11,22; Dr Kupfer17; Dr Meduri50,56; and Dr Oppert.51 These studies were supported by local institutions,15- 17,50,51,53,56 national public institutions,11,18 or by the European Community.22
Funding/Support: This review was initially developed within the Cochrane Collaboration Infectious Diseases Group, supported by a grant from the UK Department for International Development. The review was transferred to the Cochrane Collaboration Anaesthesia Group in May 2005. There was no funding for this review in particular.
Role of the Sponsors: None of the institutions/sponsors of individual studies had any role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; or preparation, review, or approval of the manuscript.
Additional Contributions: We thank Charles L. Sprung, MD, Hadassah Hebrew University Medical Center, Jerusalem, Israel, for providing unpublished data.