Study concept and design: Brubaker, Burgio, Richter, Nygaard, Barber, Menefee, Norton, Schaffer, Borello-France, Goode, Spino, Barber.
Acquisition of data: Brubaker, Richter, Nygaard, Menefee, Lukacz, Norton, Schaffer, Nguyen, Jakus-Waldman, Warren, Meikle, Barber.
Analysis and interpretation of data: Brubaker, Burgio, Nygaard, Menefee, Lukacz, Norton, Schaffer, Nguyen, Borello-France, Goode, Jakus-Waldman, Spino, Warren, Gantz, Meikle, Barber.
Drafting of the manuscript: Brubaker, Burgio, Richter, Nygaard, Barber, Menefee, Lukacz, Schaffer, Nguyen, Borello-France, Jakus-Waldman, Spino, Warren, Gantz, Meikle, Barber.
Critical revision of the manuscript for important intellectual content: Brubaker, Burgio, Richter, Nygaard, Menefee, Lukacz, Norton, Schaffer, Nguyen, Borello-France, Goode, Jakus-Waldman, Spino, Warren, Gantz, Meikle, Barber.
Statistical analysis: Spino, Warren, Gantz, Meikle, Barber.
Obtained funding: Brubaker, Burgio, Nygaard, Norton, Schaffer, Spino, Meikle, Barber.
Administrative, technical, and material support: Brubaker, Barber, Norton, Schaffer, Spino, Meikle, Barber.
Study supervision: Burgio, Richter, Menefee, Schaffer, Goode, Spino, Gantz, Meikle, Barber.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Barber reported having received a research grant from the Foundation for Female Health Awareness and royalties from UptoDate and Elsevier. Dr Brubaker reported having received royalties from UptoDate. Dr Burgio reported having received a research grant from Pfizer and being a consultant for Pfizer and Astellas. Dr Richter reported having received research grants from Astellas, the University of California/Pfizer, and Pfizer; being a consultant for the Astellas Advisory Board, GlaxoSmithKline, Uromedica, IDEO, and Xanodyne; and receiving an education grant from Warner Chilcott. Dr Lukacz reported having received a research grant from Renew Medical and an educational grant from Ethicon/Johnson & Johnson; being a consultant for Pfizer, Renew Medical, and American Medical Systems; and receiving payment for the development of educational content for Sharp Chula Vista. Dr Schaffer reported having received research support from Boston Scientific, being a consultant for Ferring Pharmaceuticals, serving on an advisory board and a speakers bureau for Astellas and Cadence Pharmaceuticals, and receiving royalties from McGraw-Hill. Dr Goode reported having received a research grant from Pfizer and serving as a consultant for Astellas. No other disclosures were reported.
Funding/Support: This research was supported by grants U01 HD041249, U10 HD041250, U10 HD041261, U10 HD041267, U10 HD054136, U10 HD054214, U10 HD054215, U01 HD069031, and U10 HD054241 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development and the National Institutes of Health Office of Research on Women’s Health.
Role of the Sponsor: The Eunice Kennedy Shriver National Institute of Child Health and Human Development project scientist for the Pelvic Floor Disorders Network, Anne Weber, MD, had a role in the study design. Dr Meikle became the project scientist just as the study was initiated and had a role in conduct of the study; the collection, analysis, and interpretation of the data; and in the preparation, review, and approval of the manuscript.
Pelvic Floor Disorders Network (PFDN) Members: In addition to the authors, the following members of the Pelvic Floor Disorders Network participated in the Operations and Pelvic Muscle Training in the Management of Apical Support Loss (OPTIMAL) trial: RTI International, Research Triangle Park, North Carolina (PFDN Data Coordinating Center, July 1, 2011, to present): Dennis Wallace, Kevin A. Wilson, Daryl Matthews, Tamara L. Terry, Jutta Thornberry, Amanda Youmans-Weisbuch, Ryan E. Whitworth, Michael P. Hieronymus. University of Michigan, Ann Arbor (PFDN Data Coordinating Center, until July 1, 2011): Morton Brown, Nancy Janz, John Wei, Xiao Xu, Beverley Marchant, Donna DiFranco, Yang Casher, Kristina Slusser, Zhen Chen. Cleveland Clinic, Cleveland, Ohio: Mark D. Walters, J. Eric Jelovsek, Marie F. R. Paraiso, Beri M. Ridgeway, Ly Pung, Cheryl Williams, Linda McElrath, Betsy O’Dougherty, Megan Edgehouse, Gouri Diwadkar, Anna Frick. Loyola University Chicago, Illinois: Mary Tulke, Elizabeth Mueller, Kimberly Kenton, Kathleen Jesse. University of California, San Diego, Health Systems: Charles W. Nager, Michael E. Albo, Cara Grimes, Heidi W. Brown, Anna C. Kirby, Leah Merrin, JoAnn Columbo, Nehal Mehta. Southern California Kaiser Permanente, Downey: Mercedes Cardona, Eudocia Zapata. Southern California Kaiser Permanente, San Diego: Emily L. Whitcomb, Keisha Y. Dyer, Karl M. Luber, Jasmine Tan-Kim, Gouri B. Diwadkar, Lynn M. Hall, Linda M. Mackinnon, Gisselle Zazueta-Damian. University of Utah, Salt Lake City: Yvonne Hsu, Jan Baker, Linda Freedman, Linda Griffin, Maria Masters, Amy Orr, Kristina Heintz. University of Alabama at Birmingham: R. Edward Varner, Robert Holley, William J. Greer, L. Keith Lloyd, Tracy S. Wilson, Alayne Markland, Jonathan L. Gleason, Alicia Ballard, Candace Parker-Autry, Lisa Pair, Velria Willis, Nancy Saxon, Lachele Ward, Kathy Carter, Julie Burge. Duke University Medical Center, Durham, North Carolina: Anthony G. Visco, Cindy L. Amundsen, Nazema Y. Siddiqui, Jennifer M. Wu, Mary Raynor, Mary McGuire, Ingrid Harm-Ernandes. University of Texas Southwestern Medical Center, Dallas: David Rahn, Marlene Corton, Clifford Wai, Kelly Moore, Shanna Atnip, Pam Martinez, Deborah Lawson. Formerly Eunice Kennedy Shriver National Institute of Child Health and Human Development: Anne Weber. PFDN Steering Committee Chair: Katherine Hartmann.