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Comment & Response |

Mortality in Patients With Hypovolemic Shock Treated With Colloids or Crystalloids—Reply

Djillali Annane, MD, PhD1; Sylvie Chevret, MD, PhD2
[+] Author Affiliations
1Raymond Poincaré Hospital, University of Versailles, Garches, France
2Saint Louis Hospital, Paris, France
JAMA. 2014;311(10):1069-1070. doi:10.1001/jama.2014.841.
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In Reply Dr Perner and colleagues suggest that allocation concealment was not ensured in the CRISTAL trial. However, procedures were in place to hide the allocation sequence until assignment. Sequentially numbered, sealed, and opaque envelopes were used. An envelope assigned to a patient was opened only after the investigator wrote patient information on it. The signed inclusion sheet with patient and randomization details was faxed to the coordinating center, allowing monitoring of treatment allocation to unique patients in appropriate order. Only 6 errors in envelope assignment were found, corresponding to simultaneous inclusion of a patient by multiple investigators in the same center. This process ensured a low risk of bias.1


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March 12, 2014
Anders Perner, MD, PhD; Nicolai Haase, MD, PhD; Jørn Wetterslev, MD, PhD
1Intensive Care Medicine, Copenhagen University Hospital, Copenhagen, Denmark
JAMA. 2014;311(10):1067. doi:10.1001/jama.2014.830.
March 12, 2014
Rinaldo Bellomo, MD, FCICM; Simon Finfer, MD, FCICM; John Myburgh, PhD, FCICM
1Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Australia
2George Institute for Global Health, University of Sydney, Sydney, Australia
JAMA. 2014;311(10):1067-1068. doi:10.1001/jama.2014.833.
March 12, 2014
Christian Brun-Buisson, MD; Junfeng Sun, PhD; Charles Natanson, MD
1Service de Réanimation Médicale, GH Henri Mondor, Créteil, France
2Department of Critical Care Medicine, National Institutes of Health Clinical Center, Bethesda, Maryland
JAMA. 2014;311(10):1068-1069. doi:10.1001/jama.2014.836.
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