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Comment & Response |

Stem Cells and Cardiovascular Drug Development—Reply

Nicholas M. Mordwinkin, PharmD, PhD1; Andrew S. Lee, PhD1; Joseph C. Wu, MD, PhD1
[+] Author Affiliations
1Stanford University School of Medicine, Stanford, California
JAMA. 2014;311(10):1070-1071. doi:10.1001/jama.2014.634.
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In Reply Drs Rao and Dlouhy mention several valid points regarding the bottlenecks of iPSC derivation and suggest that direct reprogramming to induced cardiomyocytes (iCMs) may be a more cost-effective, efficient, and safe alternative. Transdifferentiation to iCMs presents both advantages and disadvantages compared with the use of iPSC-derived cardiomyocytes. We think that both of these methods offer significant potential for the clinical treatment of cardiac disease in addition to cardiovascular drug discovery.


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March 12, 2014
Rajesh C. Rao, MD; Brian J. Dlouhy, MD
1University of Michigan Medical School, Ann Arbor
2Prince of Wales Hospital, Randwick, New South Wales, Australia
JAMA. 2014;311(10):1070. doi:10.1001/jama.2014.631.
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