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June 3, 2009, Vol 301, No. 21 >

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Letters | June 3, 2009

Effect of Preventive Supplementation on Young Children in Niger

Debashis Ghosh, PhD
JAMA. 2009;301(21):2208-2209. doi:10.1001/jama.2009.740.
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To the Editor: Ms Isanaka and colleagues1 conducted a cluster randomized trial to evaluate the effect of ready-to-use therapeutic foods on various measures of nutritional status, morbidity, and mortality in children in Niger. The cluster randomized trial design is a very useful one for this setting because of logistical constraints. However, such a design leads to analytic complications.

There are 2 levels of correlation in the study that need to be accounted for in the analysis. The first is that the children were clustered within households. This is shown in Figure 1 of the article, which indicates 1671 children from 647 households in the intervention group and 1862 children from 760 households in the control group. This leads to use of mixed-effects models in which correlation is accounted for at the village, household, and individual levels.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

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June 3, 2009
Effect of Preventive Supplementation on Young Children in Niger
Dominique Roberfroid, MD, MSc, MPhil; Lieven Huybregts, MSc; Patrick Kolsteren, MD, PhD
JAMA. 2009;301(21):2208-2209. doi:10.1001/jama.2009.739.
June 3, 2009
Effect of Preventive Supplementation on Young Children in Niger—Reply
Sheila Isanaka, BA; Rebecca F. Grais, PhD
JAMA. 2009;301(21):2208-2209. doi:10.1001/jama.2009.741.
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