Author Contributions: Dr Bell had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Bell, Hatch, Fischer, Paterson, Gill, Anderson, Rochon.
Acquisition of data: Bell, Cernat.
Analysis and interpretation of data: Bell, Hatch, Fischer, Cernat, Paterson, Gruneir, Gill, Bronskill, Anderson, Rochon.
Drafting of the manuscript: Bell, Hatch, Fischer, Paterson.
Critical revision of the manuscript for important intellectual content: Bell, Hatch, Fischer, Cernat, Paterson, Gruneir, Gill, Bronskill, Anderson, Rochon.
Statistical analysis: Bell, Cernat.
Obtained funding: Bell, Gill, Bronskill, Anderson, Rochon.
Administrative, technical, or material support: Fischer, Cernat.
Study supervision: Anderson, Rochon.
Financial Disclosures: Dr Hatch has been employed by the University of Toronto and the Toronto Western Hospital to coordinate clinical trials sponsored by Alcon and Novartis. Dr Fischer was last employed by Bayer Inc in 2004. No other authors have any potential or real conflicts of interest to declare. Dr Cernat performed the statistical analysis for this study and declares no conflicts of interest.
Funding/Support: This work was supported by Team Grant OTG-88591 from the Canadian Institutes of Health Research (CIHR) Institute of Nutrition, Metabolism, and Diabetes and by an Interdisciplinary Capacity Enhancement Grant, HOA-80075, from the CIHR Institute of Gender and Health and the CIHR Institute of Aging. Dr Bell is supported by a New Investigator Award from the CIHR Institute of Aging. This study was conducted at the Institute for Clinical Evaluative Sciences (ICES), which is funded by an annual grant from the Ontario Ministry of Health and Long-Term Care (MOHLTC).
Role of the Sponsors: The funding agencies had no role in the design and conduct of the study; collection, management, analysis, or interpretation of the data; or preparation, review, or approval of the manuscript.
Disclaimer: The opinions, results, and conclusions reported in this article are those of the authors and are independent from the funding sources. No endorsement by ICES or the Ontario MOHLTC is intended or should be inferred.