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In the April 9, 2008, issue of JAMA, an article entitled “Chemoembolization Combined With Radiofrequency Ablation for Patients With Hepatocellular Carcinoma Larger Than 3 cm: A Randomized Controlled Trial” was published by Dr Cheng and colleagues.1 We subsequently received information that raised concerns about the integrity of the data and the veracity of the report. We conducted an extensive internal investigation into these concerns, contacted the primary author of the study, and also notified Shandong University, the authors' institution, expressing our concerns about the conduct of the trial and the integrity of the data. Based on the responses we received from the authors, we continued to have concerns about the validity and integrity of the study, and therefore requested a formal investigation by the authors' institution.
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