Author Contributions: Dr Hiatt had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Berger, Hiatt.
Acquisition of data: Berger, Krantz, Hiatt.
Analysis and interpretation of data: Berger, Krantz, Kittelson, Hiatt.
Drafting of the manuscript: Berger, Krantz, Kittelson, Hiatt.
Critical revision of the manuscript for important intellectual content: Krantz, Kittelson, Hiatt.
Statistical analysis: Berger, Krantz, Kittelson, Hiatt.
Administrative, technical, or material support: Berger, Krantz.
Study supervision: Hiatt.
Financial Disclosures: Drs Hiatt and Krantz report that they have served on the US Food and Drug Administration Cardiovascular and Renal Drugs Advisory Committee in the review of antithrombotic therapies and Dr Hiatt previously reviewed the use of aspirin for primary prevention and for treatment of PAD. Drs Krantz and Hiatt report that they have received grant support for projects related to the use of clopidogrel and previously served on the speaker's bureau of the BMS-Sanofi-Aventis Partnership (speaker bureau activities ended in 2008). Dr Berger reports receiving research support from AstraZeneca and has received honoraria for advisory board participation from The Medicines Group. Dr Kittelson reports no conflicts related to this article.
Funding/Support: Dr Berger was partially funded by grants 5K12HL83772-2, a Research Career Development Award from the National Heart, Lung, and Blood Institute and 0775074N an American Heart Association Fellow to Faculty Award. Dr Krantz was partially funded by grant U01 HL079160 from National Heart, Lung, and Blood Institute.
Role of the Sponsor: There was no financial support for this manuscript.
Additional Contributions: We thank Andrew Starrett, PhD, Denver, Colorado, for his contributions to the statistical analysis, and we thank Phillippe Lechat, MD, Pharmacology Department, Pitie-Salpetriere Hospital, Paris, France, and Pascal Priollet, MD, Department of Vascular Medicine, St Joseph Hospital, Paris, France, for their suggestions on the initial conceptualization of this article. None received compensation for their contributions.