Investigators commissioned by the US Centers for Medicare & Medicaid Services (CMS) said compendia of medications used to justify off-label use for cancer treatments appear not to use systematic methods to review or update evidence. As a result, physicians using these compendia to determine treatment regimens for patients with cancer may not be prescribing the best medications for a particular case, and Medicare and other insurers may be paying for suboptimal care for such patients.
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Researchers say oncology drug compendia that update off-label prescribing for patients with cancer lack rigorous evidence of efficacy for certain indications.
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