In Reply: As Dr Gottlieb and colleagues noted, one of the main findings of our study was the frequency of detection of Klinefelter syndrome, especially in boys with persistent bilateral cryptorchidism (5/120 [4.2%; 95% confidence interval, 1.8%-9.7%]). This finding is of particular interest because the availability of early diagnosis of Klinefelter syndrome would allow better management of affected persons during puberty and early adulthood in relation to preservation of fertility and initiation of androgen replacement therapy before symptoms and signs of hypogonadism develop.
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