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March 25, 2009, Vol 301, No. 12 >

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Letters | March 25, 2009

Risk of Major Adverse Cardiovascular Events With Inhaled Anticholinergics in Patients With Chronic Obstructive Pulmonary Disease

Katherine E. Hodgin, MD; James P. Maloney, MD
JAMA. 2009;301(12):1223-1226. doi:10.1001/jama.2008.950.
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To the Editor: In the meta-analysis by Dr Singh and colleagues,1 the question was raised regarding biological causality for the increased cardiovascular mortality associated with the long-term use of tiotropium. According to the manufacturer's package insert,2 the number of participants with changes from the baseline-corrected QT interval of 30 to 60 msec was higher in the tiotropium group compared with the placebo group in a multicenter, randomized, double-blind trial of 198 patients with COPD. A lack of QTc effects with tiotropium was reported in the publication of that clinical trial; however, in that trial patients with renal impairment were excluded.3

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

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March 25, 2009
Risk of Major Adverse Cardiovascular Events With Inhaled Anticholinergics in Patients With Chronic Obstructive Pulmonary Disease
Yuji Oba, MD
JAMA. 2009;301(12):1223-1226. doi:10.1001/jama.2008.947.
March 25, 2009
Risk of Major Adverse Cardiovascular Events With Inhaled Anticholinergics in Patients With Chronic Obstructive Pulmonary Disease
Henry D. Covelli, MD
JAMA. 2009;301(12):1223-1226. doi:10.1001/jama.2008.948.
March 25, 2009
Risk of Major Adverse Cardiovascular Events With Inhaled Anticholinergics in Patients With Chronic Obstructive Pulmonary Disease
Steven Kesten, MD; Inge Leimer, PhD; Michele Jara, PhD
JAMA. 2009;301(12):1223-1226. doi:10.1001/jama.2008.949.
March 25, 2009
Risk of Major Adverse Cardiovascular Events With Inhaled Anticholinergics in Patients With Chronic Obstructive Pulmonary Disease—Reply
Sonal Singh, MD, MPH; Yoon K. Loke, MBBS, MD; Curt D. Furberg, MD, PhD
JAMA. 2009;301(12):1223-1226. doi:10.1001/jama.2008.951.
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