Ms C, a young, undocumented immigrant from Central America, was diagnosed with leukemia during the 34th week of pregnancy. She delivered a healthy daughter at term and then received chemotherapy, which achieved remission. However, bone marrow biopsy at 6 months revealed a relapse, a second round of chemotherapy was ineffective, and she was informed that a cure was not possible. Ms C signed a do-not-resuscitate–do-not-intubate order and identified as her primary goal to spend as much time as possible with her daughter. Her partner (the child's father) requested that “everything be done” and refused to participate in end-of-life care planning. Smith and colleagues discuss challenges that Latino immigrants may face in achieving optimal end-of-life care, including separation from family, barriers to health care access, language and literacy barriers, cultural norms, spiritual beliefs, and concerns about discrimination.