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Critically Ill Patients With Influenza A(H1N1)pdm09 Virus Infection in 2014

Lena M. Napolitano, MD1; Derek C. Angus, MD, MPH2,3; Timothy M. Uyeki, MD, MPH, MPP4
[+] Author Affiliations
1Acute Care Surgery, Department of Surgery, Surgical Critical Care and Trauma, University of Michigan Health System, University Hospital, Ann Arbor
2Department of Critical Care Medicine, University of Pittsburgh and UPMC Health System, CRISMA Center, Department of Critical Care Medicine, Pittsburgh, Pennsylvania
3Associate Editor, JAMA
4Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia
JAMA. 2014;311(13):1289-1290. doi:10.1001/jama.2014.2116.
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The 2009 pandemic caused by influenza A(H1N1)pdm09 virus resulted in more than 18 500 deaths reported worldwide and global estimates that were 15-fold higher.1 In contrast to seasonal influenza epidemics, during which elderly persons have the highest risk for hospitalization and death, many critically ill patients during the 2009 H1N1 pandemic were young or middle-aged adults.2 Other notable risk factors were morbid obesity and pregnancy, including the early postpartum period.2 The dominant feature of critical illness during the 2009 H1N1 pandemic was severe acute respiratory distress syndrome (ARDS) that often developed very quickly following presentation to the hospital and frequently was associated with a long and protracted course and high mortality.2

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