0
February 4, 2009, Vol 301, No. 5 >

Full Content is available to subscribers

Subscribe/Learn More
Lab Reports | February 4, 2009

Preventing Emphysema

M. J. Friedrich
JAMA. 2009;301(5):477. doi:10.1001/jama.2009.40.
Text Size: A A A
Published online
Article
Figures

Extract

Researchers studying mice exposed to cigarette smoke demonstrated that a drug that activates a key component of the lung's antioxidant defense system, nuclear factor erythroid-derived 2–related factor 2 (Nrf2), helped prevent lung damage and some types of heart damage (Sussan TE et al. Proc Natl Acad Sci U S A. 2009;106[1]: 250-255).

The investigative team, at Johns Hopkins University School of Medicine in Baltimore, exposed mice with and without Nrf2 to cigarette smoke to determine if activation of Nrf2 could prevent emphysema. Half of each group received CDDO-Im, a small molecule that can activate Nrf2. The mice with Nrf2 that received CDDO-Im were much less susceptible to heart and lung damage caused by cigarette smoke than the mice that did not possess Nrf2.
Figures in this Article

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview

Figures

Place holder to copy figure label and caption

Grahic Jump LocationImage not available.

Research suggests that the smoking-induced lung damage of emphysema (above) may be reduced by drugs that activate a part of the lung's antioxidant defense system.

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

Letters

Submit a Letter
CME
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Clear Answers | Save For Later
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s “Cited By” API will populate this tab (http://www.crossref.org/citedby.html).
Compression-Only CPR: Pushing the Science Forward
Cone
AAM 2010;304:1493-1495.
All you need to read in the other general journals
BMJ 2010;341:c5893-c1494.
Submit a Response

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
William R. Barclay, MD, 1919-2006
JAMA. 2006;295(21):2465. doi:10.1001/jama.295.21.2465.
Related Topics
PubMed Articles
Phenotyping of chronic obstructive pulmonary disease using the modified Bhalla scoring system for high-resolution computed tomography.
Can Respir J ;20(2):91-6
On the role of abnormal DLCO in ex-smokers without airflow limitation: symptoms, exercise capacity and hyperpolarised helium-3 MRI.
Thorax ;
Jobs

More Listings at
JAMACareerCenter.com >

© 2013 American Medical Association. All Rights Reserved.
Powered bySilverchair Information Systems