We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Clinical Trials Update |

Vitamin D Levels Appear to Be Robust Predictor of MS Progression

Anita Slomski
JAMA. 2014;311(8):790. doi:10.1001/jama.2014.1553.
Text Size: A A A
Published online


Higher vitamin D levels in persons with multiple sclerosis (MS) were associated with a lower degree of MS activity, magnetic resonance imaging lesion load, brain atrophy, and disease progression during 5 years of follow-up in the Betaferon/Betaseron in Newly Emerging Multiple Sclerosis for Initial Treatment (BENEFIT) trial (Ascherio A et al. JAMA Neurol. doi:10.1001/jamaneurol.2013.5993 [published online January 20, 2014]).

Some 465 patients with clinically isolated syndrome (their first neurological episode, caused by inflammation or demyelination of nerve tissue) were randomized to early vs late treatment with interferon beta-1b (IFNB-1b). Compared with those who had 25-hydroxyvitamin D serum concentrations less than 50 nmol/L in the first 12 months following their first neurological episode, those with serum levels of 50 nmol/L or greater had a significantly lower rate of new active lesions and relapse, a significantly lower yearly increase in T2 lesion volume, and lower disability during the following 4 years.

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
PubMed Articles
Multiple sclerosis: Response to vitamin D reduced in multiple sclerosis. Nat Rev Neurol Published online Sep 15, 2015;
The Roles of Vitamin D and Its Analogs in Inflammatory Diseases. Curr Top Med Chem Published online Sep 15, 2015;