Author Contributions: Dr McDermott had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: McDermott, Ades, Guralnik, Liu, Nelson, Schneider, McPherson, Laing, Criqui.
Acquisition of data: McDermott, Lloyd-Jones, Garside, Domanchuk, Stein, Green, Pearce, Laing, McCarthy, Shroff, Criqui.
Analysis and interpretation of data: McDermott, Ades, Guralnik, Dyer, Ferrucci, Liu, Nelson, Van Horn, Kibbe, Stein, Liao, Tao, McPherson, Criqui.
Drafting of the manuscript: McDermott, Ades, Dyer, Ferrucci, Laing, Shroff.
Critical revision of the manuscript for important intellectual content: McDermott, Ades, Guralnik, Dyer, Ferrucci, Liu, Nelson, Lloyd-Jones, Van Horn, Garside, Kibbe, Domanchuk, Stein, Liao, Tao, Green, Pearce, Schneider, McPherson, McCarthy, Shroff, Criqui.
Statistical analysis: Guralnik, Dyer, Ferrucci, Liu, Liao, Tao, Tao.
Obtained funding: McDermott, Liu, Criqui.
Administrative, technical, or material support: Ades, Van Horn, Garside, Domanchuk, Stein, Green.
Study supervision: McDermott, Garside, McPherson, Laing, McCarthy, Criqui.
Financial Disclosures: Dr McDermott reports having received consulting fees and honoraria from educational activities from Sanofi-Avantis and Bristol-Myers Squibb; otherwise, no other financial conflicts were reported.
Funding/Support: Supported by grants R01-HL073551 from the National Heart, Lung, and Blood Institute and by RR-00048 from the National Center for Research Resources, National Institutes of Health. This was also supported in part by the Intramural Research Program, National Institutes on Aging.
Role of the Sponsor: The funding agency played no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript.
Disclaimer: Dr McDermott, a JAMA contributing editor, was not involved in the review of or decision to publish this article.