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Comment & Response |

Short-Acting β-Blocker Administration in Patients With Septic Shock—Reply

Andrea Morelli, MD1; Christian Ertmer, MD2; Mervyn Singer, MD, FRCP3
[+] Author Affiliations
1Department of Anesthesiology and Intensive Care, University of Rome, “La Sapienza,” Rome, Italy
2Department of Anesthesiology, Intensive Care, and Pain Medicine, University of Muenster, Muenster, Germany
3Bloomsbury Institute of Intensive Care Medicine, University College London, London, England
JAMA. 2014;311(7):737-738. doi:10.1001/jama.2014.327.
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In Reply Dr Cortés and colleagues criticize the use of AUC in analyzing differences between groups due to potential baseline imbalances. However, imbalances were minimal and because AUC was calculated relative to baseline, any potential imbalance would have been adequately reflected. A linear mixed-effects model produced similar results. We concur that small differences in stroke volume and stroke work index should not be overinterpreted; however, the key message is that esmolol enabled heart rate control without deterioration of these variables.


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February 19, 2014
Gen-Min Lin, MD, MPH
1Department of Preventive Medicine, Northwestern University, Chicago, Illinois
JAMA. 2014;311(7):737. doi:10.1001/jama.2014.312.
February 19, 2014
Filippo Sanfilippo, MD, PhD; Cristina Santonocito, MD; Marc Oliver Maybauer, MD
1Oxford Heart Centre, Oxford University Hospitals, Oxford, England
2Department of Anesthesiology and Intensive Care, Philipps University, Marburg, Germany
JAMA. 2014;311(7):736-737. doi:10.1001/jama.2014.315.
February 19, 2014
Adrien Bouglé, MD; Jean-Paul Mira, MD, PhD
1School of Medicine, Paris Descartes University, Paris, France
JAMA. 2014;311(7):736-737. doi:10.1001/jama.2014.318.
February 19, 2014
Diego Orbegozo Cortés, MD; Fabio Silvio Taccone, MD; Jean-Louis Vincent, MD, PhD
1Department of Intensive Care, Erasme University Hospital, Brussels, Belgium
JAMA. 2014;311(7):735-736. doi:10.1001/jama.2014.324.
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