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Comment & Response |

Short-Acting β-Blocker Administration in Patients With Septic Shock

Filippo Sanfilippo, MD, PhD1; Cristina Santonocito, MD1; Marc Oliver Maybauer, MD2
[+] Author Affiliations
1Oxford Heart Centre, Oxford University Hospitals, Oxford, England
2Department of Anesthesiology and Intensive Care, Philipps University, Marburg, Germany
JAMA. 2014;311(7):736-737. doi:10.1001/jama.2014.315.
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To the Editor In a large randomized clinical trial of the use of a β-blocker (esmolol) in patients with severe septic shock, Dr Morelli and colleagues1 demonstrated the ability of esmolol to reduce heart rate. The use of esmolol was associated with a reduction in norepinephrine and fluid requirements and an increase in stroke volume, systemic vascular resistance, and left ventricular stroke work indices. These cardiovascular effects were not only associated with improved respiratory function and metabolic parameters but also with lower 28-day mortality.

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February 19, 2014
Andrea Morelli, MD; Christian Ertmer, MD; Mervyn Singer, MD, FRCP
1Department of Anesthesiology and Intensive Care, University of Rome, “La Sapienza,” Rome, Italy
2Department of Anesthesiology, Intensive Care, and Pain Medicine, University of Muenster, Muenster, Germany
3Bloomsbury Institute of Intensive Care Medicine, University College London, London, England
JAMA. 2014;311(7):737-738. doi:10.1001/jama.2014.327.
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