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Comment & Response |

Acute Muscle Wasting Among Critically Ill Patients

Andrew G. Day, MSc1
[+] Author Affiliations
1Clinical Research Centre, Kingston General Hospital, Kingston, Ontario, Canada
JAMA. 2014;311(6):622. doi:10.1001/jama.2013.285423.
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To the Editor Muscle wasting in critically ill patients is both pervasive and detrimental. Dr Puthucheary and colleagues1 attempted to characterize the muscle wasting process and its sequelae in critically ill patients from both a clinical and molecular perspective. Unfortunately their report contained several statistical inconsistencies.

Some 95% confidence intervals presented in the body of the article were inconsistent with Figure 2; and some confidence intervals contained zero and were thus inconsistent with statistically significant change despite P values of less than .05. In addition, Figures 2, 3, and 5 appear to be reporting means rather than medians.


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February 12, 2014
Zudin A. Puthucheary, MRCP; Mark J. W. McPhail, MRCP, PhD; Nicholas Hart, BSc, MRCP, PhD, FFICM
1Institute of Health and Human Performance, University College London, London, England
2Department of Hepatology and Gastroenterology, Imperial College London, London, England
3Lane Fox Respiratory Unit, Guy’s and St Thomas’ NHS Foundation Trust, London, England
JAMA. 2014;311(6):622-623. doi:10.1001/jama.2013.285426.
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