Author Contributions: Drs Hernandez and Curtis had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Hernandez, Shea, Schulman, Curtis.
Acquisition of data: Shea, Curtis.
Analysis and interpretation of data: Hernandez, Shea, Milano, Rogers, Hammill, O’Connor, Peterson, Curtis.
Drafting of the manuscript: Hernandez, Shea.
Critical revision of the manuscript for important intellectual content: Shea, Milano, Rogers, Hammill, O’Connor, Schulman, Peterson, Curtis.
Statistical analysis: Shea, Hammill, Curtis.
Obtained funding: Hernandez, Peterson, Curtis.
Administrative, technical, or material support: Shea, Schulman.
Study supervision: Hernandez, Schulman.
Financial Disclosures: Dr Hernandez reports receiving research support from GlaxoSmithKline, Johnson & Johnson (Scios Inc), Medtronic, Novartis, and Roche Diagnostics and honoraria from AstraZeneca, Novartis, Sanofi-Aventis, and Thoratec Corporation. Dr Milano reports receiving research support and honoraria from Thoratec Corporation, Ventracor, and Abiomed. Dr Rogers reports receiving research support and honoraria from Thoratec Corporation, Ventracor, and WorldHeart Corporation. Dr Schulman reports receiving research and/or salary support from Actelion, Allergan, Amgen, Arthritis Foundation, Astellas Pharma, Bristol-Myers Squibb, the Duke Endowment, Genentech, Inspire Pharmaceuticals, Johnson & Johnson, Kureha Corporation, LifeMasters Supported SelfCare, Medtronic, Merck, Nabi Biopharmaceuticals, National Patient Advocate Foundation, North Carolina Biotechnology Center, Novartis, OSI Eyetech, Pfizer, Roche, Sanofi-Aventis, Schering-Plough, Scios, Tengion, Theravance, Thomson Healthcare, Vertex Pharmaceuticals, Wyeth, and Yamanouchi USA Foundation; receiving personal income for consulting from Avalere Health, Johnson & Johnson, LifeMasters Supported SelfCare, McKinsey & Co, and the National Pharmaceutical Council; having equity in and serving on the board of directors of Cancer Consultants; having equity in and serving on the executive board of Faculty Connection LLC; and having equity in Alnylam Pharmaceuticals. Dr Curtis reports receiving research and salary support from Allergan Pharmaceuticals, GlaxoSmithKline, Lilly, Medtronic, Novartis, Ortho Biotech, OSI Eyetech, Pfizer, and Sanofi-Aventis. Drs Hernandez, Schulman, Peterson, and Curtis have made available online detailed listings of financial disclosures (http://www.dcri.duke.edu/research/coi.jsp). No other disclosures were reported.
Funding/Support: This study was supported in part by grants 1R01AG026038-01A1 from the National Institute on Aging and 1U18HS016964-01 from the Agency for Healthcare Research and Quality.
Role of the Sponsor: The National Institute on Aging and the Agency for Healthcare Research and Quality had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; or preparation, review, or approval of the manuscript.
Disclaimer: The content of this article is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute on Aging or the Agency for Healthcare Research and Quality. Dr Peterson, a contributing editor for JAMA, was not involved in the editorial evaluation or editorial decision making regarding publication of this article.
Previous Presentation: Presented at the American Heart Association Scientific Sessions, November 12, 2008, New Orleans, Louisiana.
Additional Contributions: We thank Damon M. Seils, MA, Duke University, for editorial assistance and manuscript preparation. Mr Seils did not receive compensation for his assistance apart from his employment at the institution where the study was conducted.