0
The World in Medicine |

Gut Bacteria and Crohn Disease

Joan Stephenson, PhD
JAMA. 2008;300(19):2239. doi:10.1001/jama.300.19.2239-b.
Text Size: A A A
Published online

Extract

A strain of bacteria that inhabit the intestine secrete anti-inflammatory chemicals that may play a role in keeping Crohn disease (CD) in check, according to findings by French researchers (Sokol H et al. Proc Natl Acad Sci U S A. doi:10.1073/pnas.0804812105 [published online ahead of print October 20, 2008]).

Scientists previously had found that patients with CD had a marked reduction in the number and types of bacteria within the Clostridium leptum group. In the new study, the researchers found that Faecalibacterium prausnitzii, a major member of this group, was particularly depleted in patients with the disorder. Furthermore, patients with CD who had a significantly lower proportion of F prausnitzii at the time of surgery were more likely to experience endoscopic relapse within 6 months; they also had a lower proportion of this bacterium compared with CD patients who were still in remission.

Figures in this Article

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
/>
First page PDF preview

Figures

Place holder to copy figure label and caption

Graphic Jump LocationImage not available.

A bacterium that inhabits the intestine but which is often depleted in patients with Crohn disease secretes anti-inflammatory chemicals that may help keep the disorder in check.

Tables

References

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Topics
PubMed Articles
Jobs
brightcove.createExperiences();