The incidence of non-Hodgkin lymphoma (NHL) increased by more than 80% between 1975 and 1991 in the United States, representing one of the largest increases of any cancer.1 While the overall NHL incidence rates began to stabilize in the late 1990s, the temporal trends varied by histologic subtype with the incidence of T/NK [natural killer]–cell lymphomas increasing 4% per year during 1992-2001 compared with 0.5% per year for B-cell lymphoma.2 Part of the overall steep increase in NHL incidence over the last several decades is due to human immunodeficiency virus (HIV) infection, although the incidence of NHL has been increasing irrespective of HIV status.3 Other pathogenic associations with NHL include viruses and bacteria (eg, human T-cell lymphotropic virus type 1,4 human herpesvirus 8,5 hepatitis C,6 and Helicobacter pylori7) and medications that cause extreme immunodeficiency. However, the etiology of NHL remains largely unknown. Furthermore, the significant geographic differences (eg, the incidence of NHL is 3-4 times more common in the United States vs Japan)8 and varying incidences by sex, age, and race in population registry data are unexplained.2,9
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 9
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.